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Beyond BRCA1/2: Pinpointing the risk of inherited breast cancer genes

November 2, 2023
Immunohistochemistry for HER2 shows positive membrane staining in this infiltrating ductal carcinoma. At the molecular level, breast cancer is typically broken down into four major subtypes — triple-negative, HER2-positive, luminal A and luminal B — each with different degrees of aggressiveness and responses to treatment. Risk can be a complicated and confounding concept, particularly when it comes to life-or-death situations like cancer. The discovery of the BRCA1 and BRCA2 genes in the 1990s enabled many…

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