alzheimers-disease

Organoids reveal how to protect the brain against dementia and ALS following traumatic injury, according to study

A traumatic brain injury (TBI) can quadruple your risk for developing dementia and increase your chances of developing neurodegenerative diseases such as ALS. In a new study scientists use lab-grown human brain structures known as organoids to offer insights into why this is the case and how to miti...
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Researchers uncover a potential method for interrupting the misfolding of tau protein that underlies neurodegenerative disease

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain. Scientists have now found potential ways to interrupt this process...
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Immunotherapy for Alzheimer's disease shows promise in mouse study

Scientists have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer's disease plaques and the LILRB4 receptor on microglia cells (purple) activates them to clean up damaging plaques (blue) in the brain....
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Blended antioxidant supplement improves cognition and memory in aged mice

Cell damage from oxidative stress is a major underlying cause of age-related cognitive and muscle strength decline. Antioxidants can reduce oxidative stress and prevent age-related health decline. A new study has found that mice administered with a blended antioxidant supplement show significant imp...
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Simulations reveal mechanism behind protein build-up in Parkinson's disease

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson's disease.

App may pave way to treatments for no. 1 dementia in under-60s

A smartphone app could enable greater participation in clinical trials for people with frontotemporal dementia (FTD), a devastating neurological disorder that often manifests in midlife.

New imaging method illuminates oxygen's journey in the brain

A new bioluminescence imaging technique has created highly detailed, and visually striking, images of the movement of oxygen in the brains of mice. The method, which can be easily replicated by other labs, will enable researchers to more precisely study forms of hypoxia in the brain, such as the den...
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Familial Alzheimer's disease transferred via bone marrow transplant in mice

Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the recipients developed Alzheimer's disease -- and at an accelerated r...
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Making long-term memories requires nerve-cell damage

Just as you can't make an omelet without breaking eggs, scientists have found that you can't make long-term memories without DNA damage and brain inflammation.

Risk factors for faster aging in the brain revealed in new study

Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.