January 15, 2025
Findings will help identify patients with breast, ovarian, pancreatic or prostate cancer who may benefit from targeted therapies ROCHESTER, Minn. — Findings from a multi-institutional, international study led by researchers from the Mayo Clinic Comprehensive Cancer Center have significantly a...
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January 15, 2025
A new Mayo Clinic study links specific microbial patterns to urinary tract infection risk following pelvic organ prolapse surgery Each year, many women undergo surgery for pelvic organ prolapse, a condition where weakened muscles and tissues allow organs like the bladder or uterus to shift and ...
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January 15, 2025
Minnesota high school wrestler Abby Gindele of the Annandale/Maple Lake Lightning. Photo courtesy of Mary Christen. In 2020, the National Collegiate Athletics Association (NCAA) approved women's wrestling as an emerging sport. Since then, athletes, coaches and other leaders have recognized that...
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January 15, 2025
Getty Images A new study has revealed a significant link between a common pregnancy complication and early heart disease in women. Researchers found that women with a history of hypertensive disorders of pregnancy (HDP) were at higher risk of developing coronary artery disease at an earlier age...
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January 15, 2025
Left: A circular OmicsFootPrint visualization shows genetic and molecular changes, with chromosomes in the outer ring and gene activity changes inside — red for increased activity, green for reduced. Right: A grid of OmicsFootPrints summarizes multi-omics data for nearly 700 cancer patients, ...
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January 9, 2025
Getty Images In a new study, Mayo Clinic researchers and collaborators have described — for the first time — the prevalence of autoimmune diseases in the U.S. Their research, published in the Journal of Clinical Investigation, reports that about 15 million people are estimated to have one o...
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January 5, 2025
Getty Images ROCHESTER, Minn. — The Minnesota Partnership for Biotechnology and Medical Genomics (MNP) has announced its four research awardees for 2024. MNP is funded by the State of Minnesota and provides support for innovative research conducted by teams from the University of Minnesota ...
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January 4, 2025
Mayo Clinic Comprehensive Cancer Center researchers spent 2024 mining patient data, leveraging artificial intelligence and conducting clinical trials to reveal insights that improve patient care. By Mayo Clinic staff Mayo Clinic Comprehensive Cancer Center physicians and scientists are research...
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January 4, 2025
ROCHESTER, Minn. — At Mayo Clinic, researchers published more than 10,000 scientific papers in 2024 that are driving medical discoveries, leading to new cures for the future. The following are 10 research highlights from Mayo Clinic this year: Microscopic view of an intestinal organoid Growin...
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January 1, 2025
In 2024, collaborative efforts with Mayo Clinic's Center for Individualized Medicine led to significant advances in understanding the biology that shapes health and disease. From new treatments for rare diseases to artificial intelligence-powered tools that help personalize care, these 10 stud...
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Methylphenidate differentially affects the social ultrasonic vocalizations of wild-type and prodromal Parkinsonian rats.
Prodromal signs of Parkinson’s disease (PD), including vocal communication deficits, are poorly understood and do not respond adequately to current pharmacologic treatments. Norepinephrine dysfunction is involved early in PD; thus, drug therapies targeting norepinephrine may be useful as a treatment of prodromal signs. This study used a validated, translational rodent model of prodromal PD, the male Pink1−/− rat, which exhibits ultrasonic vocalization (USV) deficits as early as 2 months of age. The purpose of this preclinical study was to investigate a dose-dependent (2.5, 5.0, 7.5, 10 mg/kg) response of methylphenidate on USV parameters with the hypothesis that methylphenidat...
Progesterone treatment is not necessary for sexual experience-enhanced paced mating behavior in estradiol benzoate-primed female rats.
Sexual behavior in female rats varies depending on sexual history and the combination of ovarian hormones administered to induce receptivity. Experiment 1 tested whether paced mating behavior differed in sexually experienced rats when receptivity was induced with sequential estradiol benzoate (EB) and progesterone (P) or EB-Alone. Rats gained paced mating experience under EB/P (10 μg EB 48 hr + 1 mg P 4–6 hr before mating) and then were primed with EB-Alone (2 μg EB for 6 days). Rats primed with EB-Alone were fully receptive but returned to the male more slowly, spent less time with the male, had longer interintromission intervals, showed fewer proceptive behaviors and more rejection beh...
Acute early life stress alters threat processing in adult rats.
Individuals diagnosed with stress-related psychiatric disorders in adulthood are likely to have experienced early life stress, suggesting that early adversity is an important vulnerability factor in the subsequent development of trauma- and anxiety-related psychiatric illness. It is important to develop animal models of psychiatric dysfunction to determine evident vulnerability considerations, potential biomarkers, and novel treatment avenues to improve the human condition. In our model of acute early life stress (aELS), 15 footshocks are delivered in a single session on postnatal day 17. The following experiments investigated the persistent impacts of our aELS procedure on stress-enhanced f...
Dopamine-mediated behavioral alterations following exposure to a social video in socially isolated mice during the developmental period.
Video exposure is known to affect brain function, yet its impact on neurodevelopmental processes remains unclear. This study aimed to investigate whether exposure to a video depicting social behavior induces behavioral and neurological changes in socially isolated mice. On Postnatal Day (PND) 21, male mice were separated from their dams and randomly assigned to three groups: socially grouped mice; socially isolated mice (ISO), where mice were housed without any social stimulation; and social video-exposed mice (SVE), where mice were exposed to a social video played on a tablet from PND21 to PND56 under socially isolated conditions. On PND56, all animals underwent behavioral tests. Compared t...
Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long–Evans rats after moderate prenatal alcohol exposure.
Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their spatial behaviors around centralized locations, termed home bases, from which they make circuitous and slow locomotor trips (progressions) into the rest of the environment. Open-field behaviors are organized even under darkened test conditions, suggesting a role for self-motion cues (vestibular, motor, etc.). The impact of moderate prenatal alcohol exposure (mPAE) on the organization of spontaneous open-field behaviors under darkened conditions has not been investigated. Here we tested adult female and m...