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Genetic brain disorder fixed in mice using precision epigenome editing

December 10, 2019
This post was originally published on this site

Using a targeted gene epigenome editing approach in the developing mouse brain, researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people. This specific editing was unique in that it changed the epigenome — how the genes are regulated — without changing the actual genetic code of the gene being regulated.

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