IBCCES is the global leader in training and certification for healthcare professionals, educators and corporate partners who work with individuals with autism and other cognitive disorders. Our reach extends to more than 2 million people in all 50 states and over 70 countries around the globe. IBCCES Member Learning Community is provided as a free service to all IBCCES members who have completed one or more of our training and certification programs.

Re: Remove barriers to clinical research for schedule 1 drugs with therapeutic potential

May 11, 2023
I Agree

Dear Editor

Braillon and Naudet (1) raise a number of points regarding our original article (2). Firstly, in our statement that “the misuse of controlled drugs intended for clinical use is extremely rare”, we were referring to the situation where they are administered in clinical settings. Misuse of controlled drugs when dispensed as prescription medicines to be taken without supervision at home certainly does occur, but that is an entirely different matter. Psychedelic drugs are only used very intermittently in clinical therapy and in carefully managed environments. We do not see that situation encouraging misuse.

Secondly, Braillon and Naudet (1) list some of the harmful properties of psilocybin. Importantly, we never suggested that psilocybin is harmless. What we did say is that “numerous studies have shown that they cause far less harm to individuals and society than many other psychoactive drugs”, and we gave the example of heroin.

Finally, Braillon and Naudet (1) note that the real challenge with using psychedelic drugs is the quality of clinical research. We entirely agree. Many of these problems have recently been discussed by Aday et al. (3), and include: how rigorous studies should be designed particularly the need for double-blinded randomized trials; a full understanding of the risks involved; and a better understanding of the mechanism of action.


1 Braillon A, Naudet F. Clinical research and schedule 1 drugs: is the issue about legal barriers or poor quality? https://www.bmj.com/content/381/bmj.p981/rapid-responses

2 King LA, Nutt DJ, Nichols DE. Remove barriers to clinical research for schedule 1 drugs with therapeutic potential. BMJ. 2023;381:p981. doi:10.1136/bmj.p981

3 Aday JS, Carhart-Harris RL, Woolley JD. Emerging challenges for psychedelic therapy. JAMA Psychiatry. 2023; https://www.researchgate.net/profile/Jacob-Aday/publication/370124564_Em…

11 May 2023

Leslie King
David Nutt
David Nichols

No competing Interests: 
No competing interests
The following competing Interests: 
Please see the statement in our original article.
Electronic Publication Date: 
Thursday, May 11, 2023 – 06:16
Workflow State: 
Full Title: 

Re: Remove barriers to clinical research for schedule 1 drugs with therapeutic potential

Check this box if you would like your letter to appear anonymously:: 
Last Name: 
First name and middle initial: 
Leslie A
Forensic Science Service, UK
Other Authors: 
David J Nutt, David E Nichols
BMJ: Additional Article Info: 
Rapid response

Go to Source
Author: Anonymous

Powered by WPeMatico