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Science Saturday: Could antidepressants cause treatment-emergent mania?
March 2, 2023
In a study published in Molecular Psychiatry, Mark Frye, M.D., a Mayo Clinic researcher and collaborators, investigated the risk of treatment-emergent mania in bipolar disorder when treated with antidepressants. “We found that antidepressants that increase mitochondrial energetics (cells that extract energy from nutrients for sustaining life) may elevate the risk of treatment-emergent mania,” says Dr. Frye. The increased energy expenditure of mania associated with impulsivity, poor judgment, psychosis and loss of insight can drive high-risk behaviors, often…
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