July 28, 2023
Bioprinted Skin Mayo Clinic has developed its first 3D prototype of human skin bioprinted to model inflammatory skin disease. 3D bioprinting is a technology that mixes bioinks with living cells to print natural tissue-like structures in three dimensions. This new technology provides the most hu...
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July 28, 2023
Confocal microscopy image of a tissue sample showing brain cells in the external globus pallidus (red) that are important for suppressing addictive-like behaviors. Courtesy of Matthew Baker, Ph.D. As a graduate student conducting basic science research, Matthew Baker, Ph.D., focused over the ...
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July 22, 2023
Nine people around the world who have been living with unexplained, muscular dystrophy-like symptoms may now have an answer for what is causing the progressive muscle weakness in their body’s mid-section, arms and legs. In a new discovery, a collaborative team of scientists led by researchers...
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July 15, 2023
In a pilot study of 165 people, Mayo Clinic researchers looked at the effectiveness of two different approaches to weight loss: a standard lifestyle intervention and individualized therapy. The standard lifestyle intervention included a reduced diet, exercise and behavior therapy. The individua...
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July 13, 2023
The Food and Drug Administration (FDA) granted traditional approval of a disease-modifying treatment that could potentially give some patients with Alzheimer's disease something they haven’t had before: a medication that may slow the decline of memory and thinking. A monoclonal antibody, l...
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July 8, 2023
The Yale University-Mayo Clinic Center of Excellence in Regulatory Science and Innovation (CERSI), a joint effort between Yale University, Mayo Clinic and the Food and Drug Administration (FDA) to conduct research and develop tools to support regulatory decision-making, has received renew...
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July 8, 2023
Summertime is ideal for exploring possible life paths. For undergraduate students joining Mayo’s Summer Undergraduate Research Fellowship (SURF) program, the experience is sometimes the first step toward a career in biomedical research and medicine. As of June, the 2023 class of SURF students...
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July 2, 2023
ROCHESTER, Minn. — A study published in the Journal of the American College of Surgeons reveals that performing a minor surgical procedure on patients newly diagnosed with pancreatic cancer helps to identify cancer spread early and determine the stage of cancer. The researchers add that the s...
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June 30, 2023
NEWS RELEASE ROCHESTER, Minn. - A Mayo Clinic study published in Journal of Translational Medicine evaluated the use of genomic testing broadly for rare diseases. With the increased use of genomic testing such as multi-gene panels, exome sequencing and genome sequencing in the past decade, ther...
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June 30, 2023
Systemic lupus erythematosus (SLE)—a challenging autoimmune disease most common in women of childbearing age—can cause many problems in the body, including chronic pain. Typical pain management strategies are not always available to patients with lupus. For example, patients with kidney pr...
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Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.
Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate potency whose principal active compounds are psilocybin and psilocin. Recent studies have shown the significant procognitive and mood-enhancer effects of Psilocybe cubensis. However, evidence is so limited, especially in preclinical studies. We aimed to investigate the effect of Psilocybe cubensis extract on posttraumatic stress disorder (PTSD)-like behavior, pain perception, locomotor activity, and anxiety in a rat model of PTSD. Male rats were exposed to three consecutive shocks (0.8 mA, 3 s interval) paired with three sounds broadcasted 3 s before delivering shocks (75 dB, 3 s). After 1, 3, or 21 days, fre...
Sex similarities and dopaminergic differences in interval timing.
Rodent behavioral studies have largely focused on male animals, which has limited the generalizability and conclusions of neuroscience research. Working with humans and rodents, we studied sex effects during interval timing that requires participants to estimate an interval of several seconds by making motor responses. Interval timing requires attention to the passage of time and working memory for temporal rules. We found no differences between human females and males in interval timing response times (timing accuracy) or the coefficient of variance of response times (timing precision). Consistent with prior work, we also found no differences between female and male rodents in timing accura...
Less is more: Smaller hippocampal subfield volumes predict greater improvements in posttraumatic stress disorder symptoms over 2 years.
Posttraumatic stress disorder (PTSD) is a heterogeneous disorder, and symptom severity varies over time. Neurobiological factors that predict PTSD symptoms and their chronicity remain unclear. This study investigated whether the volume of the hippocampus and its subfields, particularly cornu ammonis (CA) 1, CA3, and dentate gyrus, are associated with current PTSD symptoms and whether they predict PTSD symptom changes over 2 years. We examined clinical and structural magnetic resonance imaging measures from 252 trauma-exposed post-9/11 veterans (159 with Time 1 PTSD diagnosis) during assessments approximately 2 years apart. Automated hippocampal subfield segmentation was performed with FreeSu...
Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors.
The cannabinoid system is being researched as a potential pharmaceutical target for a multitude of disorders. The present study examined the effect of indirect and direct cannabinoid agonists on mesolimbic dopamine release and related behaviors in C57BL/6J (B6) mice. The indirect cannabinoid agonist N-arachidonoyl serotonin (AA-5-HT) indirectly agonizes the cannabinoid system by preventing the metabolism of endocannabinoids through fatty acid amide hydrolase inhibition while also inhibiting transient receptor potential vanilloid Type 1 channels. Effects of AA-5-HT were compared with the direct cannabinoid receptor Type 1 agonist arachidonoyl-2′-chloroethylamide (ACEA). In Experiment 1, mic...
Lrp8 knockout mice fed a selenium-replete diet display subtle deficits in their spatial learning and memory function.
Selenium is an essential trace element that is delivered to the brain by the selenium transport protein selenoprotein P (SEPP1), primarily by binding to its receptor low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), at the blood–brain barrier. Selenium transport is required for several important brain functions, with transgenic deletion of either Sepp1 or Lrp8 resulting in severe neurological dysfunction and death in mice fed a selenium-deficient diet. Previous studies have reported that although feeding a standard chow diet can prevent these severe deficits, some motor coordination and cognitive dysfunction rem...
