Research

Asthma burden score reflecting patient experience may improve symptom management
February 16, 2025
In a Mayo Clinic-led study, researchers propose a new, personalized approach to asthma using patient-centered information based on healthcare burden data.Powered by WPeMatico...
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Mayo Clinic researchers and surgeons test virtual reality to calm presurgery jitters  
February 16, 2025
ROCHESTER, Minn. — Heart surgery is a serious and invasive medical procedure, and that can be intimidating for a patient. A new study published in Mayo Clinic Proceedings suggests that virtual reality (VR) can be an effective tool to reduce preoperative anxiety in older patients undergoing th...
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Tomorrow’s Cure: Groundbreaking advancements in larynx transplant
February 14, 2025
Researchers are pioneering innovative ways to restore voice to those who have lost it, leveraging advancements in transplant surgery and 3D printing. Discover these groundbreaking developments in the latest episode of Tomorrow's Cure. Dr. David Lott, associate director of Mayo Clinic's Center f...
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Tomorrow’s Cure: Predicting disease risk with polygenic risk scores
February 5, 2025
Imagine knowing your risk for disease long before symptoms appear. With early detection and targeted interventions, this knowledge could transform how complex healthcare challenges are addressed. Researchers are now leveraging genetic data to enhance disease risk prediction through an innovativ...
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Mayo Clinic opens new doors in cancer treatment innovation 
January 31, 2025
This 3d rendering shows antibody drug conjugates delivering therapy to cancer cells. Getty Images. Antibody-drug conjugates are targeted cancer therapies. They deliver potent drugs directly into cancer cells while minimizing harm to healthy tissue. These therapies work by recognizing specific p...
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Student’s research aims to uncover new biomarkers for Krabbe disease
January 31, 2025
Krabbe disease is a rare, inherited neurological disease that most commonly affects infants, but can also present later in life, including during adolescence and very rarely in adulthood, according to the NIH's National Institute of Neurological Disorders and Stroke. Current clinical laboratory...
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Thinking outside the box: Uncovering a novel approach to brainwave monitoring
January 26, 2025
Mayo Clinic researchers can more precisely detect and monitor brain cell activity during deep brain stimulation, a treatment for Parkinson's disease and tremor.Powered by WPeMatico...
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3D models of uveal melanoma offer hope for improved treatments
January 25, 2025
Mayo Clinic researchers have developed organoid models to study uveal melanoma, one of the most common types of eye cancer in adults. Their goal is to use these models to better understand how this disease works and develop treatments for unmet patient needs....
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Skin disease patients show response to targeted treatment
January 19, 2025
Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals. They described their findings in a study recently published in the Journal of Clinical Inve...
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8 common health conditions midlife women face
January 17, 2025
Getty Images A study published in Menopause provides a comprehensive overview of the most common conditions diagnosed in clinical practice among women in the U.S. Upper Midwest during their critical midlife transition. Overall, eight conditions increased by 45% or more between the ages of 40 an...
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Methylphenidate differentially affects the social ultrasonic vocalizations of wild-type and prodromal Parkinsonian rats.
Prodromal signs of Parkinson’s disease (PD), including vocal communication deficits, are poorly understood and do not respond adequately to current pharmacologic treatments. Norepinephrine dysfunction is involved early in PD; thus, drug therapies targeting norepinephrine may be useful as a treatment of prodromal signs. This study used a validated, translational rodent model of prodromal PD, the male Pink1−/− rat, which exhibits ultrasonic vocalization (USV) deficits as early as 2 months of age. The purpose of this preclinical study was to investigate a dose-dependent (2.5, 5.0, 7.5, 10 mg/kg) response of methylphenidate on USV parameters with the hypothesis that methylphenidat...
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Progesterone treatment is not necessary for sexual experience-enhanced paced mating behavior in estradiol benzoate-primed female rats.
Sexual behavior in female rats varies depending on sexual history and the combination of ovarian hormones administered to induce receptivity. Experiment 1 tested whether paced mating behavior differed in sexually experienced rats when receptivity was induced with sequential estradiol benzoate (EB) and progesterone (P) or EB-Alone. Rats gained paced mating experience under EB/P (10 μg EB 48 hr + 1 mg P 4–6 hr before mating) and then were primed with EB-Alone (2 μg EB for 6 days). Rats primed with EB-Alone were fully receptive but returned to the male more slowly, spent less time with the male, had longer interintromission intervals, showed fewer proceptive behaviors and more rejection beh...
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Acute early life stress alters threat processing in adult rats.
Individuals diagnosed with stress-related psychiatric disorders in adulthood are likely to have experienced early life stress, suggesting that early adversity is an important vulnerability factor in the subsequent development of trauma- and anxiety-related psychiatric illness. It is important to develop animal models of psychiatric dysfunction to determine evident vulnerability considerations, potential biomarkers, and novel treatment avenues to improve the human condition. In our model of acute early life stress (aELS), 15 footshocks are delivered in a single session on postnatal day 17. The following experiments investigated the persistent impacts of our aELS procedure on stress-enhanced f...
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Dopamine-mediated behavioral alterations following exposure to a social video in socially isolated mice during the developmental period.
Video exposure is known to affect brain function, yet its impact on neurodevelopmental processes remains unclear. This study aimed to investigate whether exposure to a video depicting social behavior induces behavioral and neurological changes in socially isolated mice. On Postnatal Day (PND) 21, male mice were separated from their dams and randomly assigned to three groups: socially grouped mice; socially isolated mice (ISO), where mice were housed without any social stimulation; and social video-exposed mice (SVE), where mice were exposed to a social video played on a tablet from PND21 to PND56 under socially isolated conditions. On PND56, all animals underwent behavioral tests. Compared t...
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Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long–Evans rats after moderate prenatal alcohol exposure.
Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their spatial behaviors around centralized locations, termed home bases, from which they make circuitous and slow locomotor trips (progressions) into the rest of the environment. Open-field behaviors are organized even under darkened test conditions, suggesting a role for self-motion cues (vestibular, motor, etc.). The impact of moderate prenatal alcohol exposure (mPAE) on the organization of spontaneous open-field behaviors under darkened conditions has not been investigated. Here we tested adult female and m...
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