Research

More than 90 articles from 25 countries featured in Mayo Clinic Proceedings: Digital Health journal’s first year
April 13, 2024
Mayo Clinic Proceedings: Digital Health, an open-access companion journal to the widely read and cited Mayo Clinic Proceedings, is marking its first anniversary, having published more than 90 articles on the digital transformation of healthcare internationally. Authors published in Mayo Clinic ...
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Mayo Clinic study finds active workstations may improve cognitive performance
April 7, 2024
ROCHESTER, Minn. — A recent Mayo Clinic study suggests that active workstations incorporating a walking pad, bike, stepper and/or standing desk are successful strategies for reducing sedentary time and improving mental cognition at work without reducing job performance. Extended sedentary beh...
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New heated drug baths provide hope for patients with stomach cancer
April 7, 2024
Mayo Clinic researchers used a new approach to chemotherapy to more than double the typical survival rate for patients with stomach cancer and peritoneal metastasis, which is cancer that has spread to the lining of the abdominal cavity.Powered by ...
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New study finds triple-negative breast cancer tumors with an increase in immune cells have lower risk of recurrence after surgery
April 5, 2024
ROCHESTER, Minn. — A new multicenter, international study suggests that people who have early-stage triple-negative breast cancer (TNBC) and high levels of immune cells within their tumors may have a lower risk of recurrence and better survival rates even when not treated with chemotherapy. T...
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Could CAR-T cell therapy improve kidney transplants?
April 5, 2024
Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) could provide a revolutionary approach to organ transplantation for patients who are hard to match and susceptible to rejection, Mayo Clinic researchers discovered. Their pioneering research focuses on using CAR-T cells derived from ...
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Mayo Clinic, Terasaki Institute launch collaboration for transplant innovation
April 4, 2024
JACKSONVILLE, Fla. — Mayo Clinic and Terasaki Institute for Biomedical Innovation announced today a research collaboration centered on improving organ transplant outcomes. Beginning in April, Mayo Clinic biomedical researchers and Terasaki Institute scientists will work together on two core a...
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Study documents safety, improvements from stem cell therapy after spinal cord injury
April 4, 2024
ROCHESTER, Minn. — A Mayo Clinic study shows stem cells derived from patients' own fat are safe and may improve sensation and movement after traumatic spinal cord injuries. The findings from the phase 1 clinical trial appear in Nature Communications. The results of this early research offer i...
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Social isolation linked to biological age gap, higher mortality rate
April 4, 2024
Mayo Clinic research finds a connection between Social Network Index score and AI-determined biological age ROCHESTER, Minn. — A new study from Mayo Clinic finds that socially isolated people are more likely to show signs of being biologically older than their age and more likely to die from ...
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Diversity science researcher achieving goal of making difference in people’s lives
February 15, 2024
From the time she was a young woman, Gladys Asiedu, Ph.D., knew she wanted to help people. Her path to achieving that goal began in Ghana. Learn about her journey and the difference she is making as a diversity science researcher. Gladys Asiedu, Ph.D., always knew she wanted to make a differenc...
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Aspiring innovators aim to transform medicine with the next big idea
February 15, 2024
Residents and students at Mayo Clinic learning the craft of their careers are also adopting a mindset to transform healthcare. Programs at Mayo are helping these enterprising inventors ask the right questions and take the steps to bring their innovative ideas to market....
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Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats.
Maintaining abstinence and preventing relapse are key to the successful recovery from alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain from alcohol use: forced (e.g., incarceration) and voluntary. Voluntary abstinence is often evoked due to the negative consequences associated with excessive alcohol consumption. This study investigated relapse-like behavior to alcohol seeking following acute, forced, and voluntary abstinence. Male rats had increased operant self-administration responding throughout training compared to females; however, females consumed greater amounts of alcohol in g/kg. Both male and female rats achieved voluntary abstinence, whic...
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Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence?
The temporal resolution power (TRP) hypothesis states that individuals with higher TRP, as reflected by a higher performance on several psychophysical timing tasks, perform better on intelligence tests due to their ability to process information faster and coordinate their mental operations more effectively. It is proposed that these differences in TRP are related to the rate of a master clock based on neural oscillations. The present study aimed to investigate whether the peak alpha frequency (PAF) measured via electroencephalography (EEG) reflects a psychophysiological measure of this rate and its potential role in explaining the relationship between TRP and psychometric intelligence. A sa...
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Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia.
Previous studies have shown that low doses of ketamine, an N-methyl-D-aspartate receptor antagonist, produce aberrantly strong internal representations of associatively activated but absent stimuli in humans and nonhuman animals, suggesting the validity of ketamine treatment as a preclinical model of the positive symptoms of schizophrenia, including hallucinations and delusions. However, whether acute ketamine treatment also impairs the ability to ignore present but informationally redundant stimuli, which is another hallmark of schizophrenia, remains unclear. Accordingly, the present study investigated whether injections of low-dose ketamine attenuate Kamin blocking in an appetitive conditi...
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Predictions about reward outcomes in rhesus monkeys.
Human infants and nonhuman animals respond to surprising events by looking longer at unexpected than expected situations. These looking responses provide core cognitive evidence that nonverbal minds make predictions about possible outcomes and detect when these predictions fail to match reality. We propose that this phenomenon has crucial parallels with the processes of reward prediction error, indexing the difference between expected and actual reward outcomes. Most work on reward prediction errors to date involves neurobiological techniques that cannot be implemented in many relevant populations, so we developed a novel behavioral task to assess monkeys’ predictions about reward outcomes...
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Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.
Drug exposure during adolescence, when the “reward” circuitry of the brain is developing, can permanently impact reward-related behavior into adulthood. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids. One reward-related behavior that develops during adolescence is social behavior. We previously demonstrated that developmental changes in the nucleus ...
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