Research

Science Saturday: A preclinical step toward treating chronic dry mouth
December 7, 2022
Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellula...
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Science Saturday: Researchers find other diseases may mimic rare brain disorder linked to dementia
December 1, 2022
Mayo Clinic researchers and collaborators have identified key clinical findings that can help clinicians recognize patients with potentially treatable causes of rapidly progressive dementia, who would otherwise be misdiagnosed with Creutzfeldt-Jakob disease (also known as CJD). Their study wa...
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Real-world evidence study of regenerative medicine and shoulder surgery
November 20, 2022
Applying regenerative medicine to a common shoulder surgery could have an impact on the need for follow-up revision surgery in some patients, according to a Mayo Clinic study of real-world evidence.Mayo Clinic researchers analyzed the largest set of data available to determine if adding bone ...
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Science Saturday: Seeking a cellular therapy for chronic kidney disease
November 19, 2022
Every year, more than 130,000 people in the U.S. are diagnosed with end-stage kidney disease, with most cases caused by diabetes. Newer therapies show promise to slow kidney failure rates, but none stop progression to end-stage kidney failure. The research goal of LaTonya Hickson, M.D., is to ...
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AI transforms smartwatch ECG signals into a diagnostic tool for heart failure
November 19, 2022
Two health tech advances are at the heart of a study published in Nature Medicine: an app and backend infrastructure to let patients remotely share smartwatch ECG data with their clinicians in an easy and secure way, and the modification of a proven 12-lead ECG artificial intelligence (AI) algo...
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Trailblazing scientists discuss exposome research, precision nutrition at Mayo Clinic’s Individualizing Medicine Conference   
November 19, 2022
ROCHESTER, Minn. — The next frontier in individualized medicine is here. Mayo Clinic's 11th annual Individualizing Medicine Conference on Nov. 2–3 will focus on "Exploring the Exposome" — the cumulative measure of environmental influences and associated biological responses throughout the...
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Science Saturday: AI enables early identification, intervention in debilitating lung disease
November 19, 2022
In a new study published in Nature Medicine, Mayo Clinic and several research collaborators from across the U.S., describe a successful new artificial intelligence, or AI, -enabled tool to identify idiopathic pulmonary fibrosis, also called IPF, before patients have recognizable symptoms. Th...
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High adopters of AI-enabled screening tool are more likely to diagnose left ventricular dysfunction than low adopters, Mayo Clinic study finds
November 19, 2022
ROCHESTER, Minn. — Artificial intelligence can improve diagnosis and treatment for patients, but first the AI-enabled clinical tools have to be easily available and used. New research from Mayo Clinic finds that clinicians who were high adopters of an AI-enabled clinical decision support tool...
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Science Saturday: Mayo Clinic study indicates U.S. rural counties have higher diabetes-related deaths
November 19, 2022
In a new study, Mayo Clinic researchers identified substantial health disparities in rural versus urban areas in diabetes-related deaths, with other disparities based on gender. Using nationwide data from the Centers for Disease Control and Prevention, the researchers examined rates and trends...
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Beating the odds for a transplant
November 19, 2022
When the phone rang in the middle of a Sunday night news program, and the caller ID flashed Mayo Clinic, Dennis Pinkerton and his wife, Rhonda, knew it was a pivotal moment. The doctor on the line delivered news he thought he'd never hear. A pair of donor lungs — kept alive and breathing on a...
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Neuroscience research on human visual path integration: Topical review of the path completion paradigm and underlying role of the hippocampal formation from a strategic perspective.
Over the past 30 years, numerous neuroscientific studies involving both human and rodent subjects have investigated the brain regions and networks supporting path integration and sought to identify the underlying neural mechanisms. Although these studies contributed to an increased understanding of path integration, a full picture of the brain mechanisms supporting path integration remains wanting. Hence, the current review was conducted with the aim of presenting an overview of the most notable neuroscientific studies on visual path integration in humans, identifying the commonalities and discrepancies in their findings, and introducing fresh ideas for future research. Specifically, this re...
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Lack of robust associations between prepandemic coping strategies and frontolimbic circuitry with depression and anxiety symptoms during the COVID-19 pandemic: A preregistered longitudinal study.
The COVID-19 pandemic is an ongoing stressor that has resulted in the exacerbation of mental health problems worldwide. However, longitudinal studies that identify preexisting behavioral and neurobiological factors associated with mental health outcomes during the pandemic are lacking. Here, we examined associations between prepandemic coping strategy engagement and frontolimbic circuitry with internalizing symptoms during the pandemic. In 85 adults (71.8% female; age 18–30 years), we assessed prototypically adaptive coping strategies (Connor–Davidson Resilience Scale), resting-state functional magnetic resonance imaging functional connectivity (FC) of frontolimbic circuitry, and depress...
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Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice.
Repetitive bouts of binge drinking can lead to neuroplastic events that alter ethanol’s pharmacologic effects and perpetuate excessive consumption. The corticotropin-releasing factor (CRF) system is an example of ethanol-induced neuroadaptations that drive excessive ethanol consumption. Our laboratory has previously shown that CRF antagonist, when infused into the central amygdala (CeA), reduces binge-like ethanol consumption. The present study extends this research by assessing the effects of silencing CRF-producing neurons in CeA on binge-like ethanol drinking stemming from “Drinking in the Dark” (DID) procedures. CRF-ires-Cre mice underwent surgery to infuse Gi/o-coupled ...
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The rostral medial frontal cortex is crucial for engagement in consummatory behavior.
The medial frontal cortex (MFC) in rodents emits rhythmic activity that is entrained to the animal’s licking cycle during consumption and encodes the value of consumed fluids. These signals are especially prominent in the rostral half of the MFC. This region is located above an orbitofrontal region where mu-opioid receptors regulate intake and reversible inactivation reduces behavioral measures associated with the incentive value and palatability of liquid sucrose. Here, we examined the effects of reversible inactivation and stimulation of mu-opioid receptors in rostral MFC on behavior in an incentive contrast licking task. Adult male rats licked to receive access to liquid sucrose, which ...
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Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues.
Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged rats show robust impairments on a number of different spatial navigation tasks. There is some evidence that these navigation impairments are accompanied by a bias toward relying on egocentric over allocentric navigation strategies. To test the degree to which young and aged animals utilize these two navigation approaches, a novel behavioral arena was used in which rats are trained to traverse a circular track and to stop at a learned goal locat...
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