alzheimers-disease

Promising 'first' in Alzheimer's drug development

An international team of researchers have made a promising breakthrough in the development of drugs to treat Alzheimer's Disease. For the first time, scientists have developed a drug that works on both major aggregation-promoting 'hotspots' of the Tau protein in the brain -- a key driver of neurodeg...
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Dementia diagnostic markers change with time of day

The time of day when blood is taken can affect the results of tests for diagnosing dementia, according to new research.

Research in 4 continents links outdoor air pollution to differences in children's brains

A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is associated with cognitive function, connections throughout the bra...
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Neuroscientists spark shelter-seeking response by reactivating memory circuit

Using a sophisticated brain-imaging system, neuroscientists say they have successfully reactivated a specific memory circuit in mice, causing them to seek out shelter when no shelter is actually present.

Alzheimer's genetic risk factors spark inflammation in females

Investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.

New study suggest treatments that maintain the health of synapses may help prevent, mitigate the symptoms of prion disease

The most common cause of inherited prion diseases is the E200K mutation of the prion protein (PrP). It is often thought that this mutation causes disease by making PrP more susceptible to misfolding into a pathogenic shape (PrPSc). However, new research has found that the architecture of neuron-to-n...
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Study of former NFL players finds 1 in 3 believe they have CTE

A study of nearly 2,000 former NFL players shows one-third believe that they have chronic traumatic encephalopathy (CTE). Those individuals were more likely to report cognitive symptoms, and 25% of them also reported suicidal thoughts. The players who thought they had CTE also were more likely to ha...
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Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.

Higher levels of leptin indicate brain protection against late-life dementia

A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults.

Understanding changes in pre-clinical Alzheimer's disease

A new study provides important insight into how amyloid-beta and tau proteins impact brain activity and possibly contribute to cognitive decline in Alzheimer's disease.