Alzheimer’s

In surprising twist, some Alzheimer’s plaques may be protective, not destructive
April 15, 2021
One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. New research upends conventional views of the origin of one prevalent type of ...
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Power of light and oxygen clears Alzheimer’s disease protein in live mice
April 13, 2021
A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer's disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other di...
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New way to monitor and prevent nerve cell deterioration after TBI
April 13, 2021
Researchers have discovered a new way to prevent brain nerve cells from deteriorating after injury, which also revealed a potential mechanistic link between TBI and AD. Their discovery also yielded a new blood biomarker of nerve cell degeneration after injury, which is significant because there is a...
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Profound loss of pleasure related to early-onset dementia
April 12, 2021
Loss of the ability to experience pleasure - or anhedonia - has been revealed as a key feature in frontotemporal dementia, in contrast to Alzheimer's disease. The findings from brain scans, believed to be a first, show grey matter deterioration in the so-called pleasure system of the brain - these r...
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Imbalance in gum bacteria linked to Alzheimer’s disease biomarker
April 12, 2021
Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta -- a key biomarker for Alzheimer's disease -- in their cerebrospinal fluid, according to new research. However, this imbalance in oral bacteria was not associated with another Alzheim...
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Aluminum is intricately associated with the neuropathology of familial Alzheimer’s disease
April 9, 2021
A new study continues to support a growing body of evidence that aluminum contributes to the pathogenesis of Alzheimer's disease (AD). Researchers found aluminum co-located with phosphorylated tau protein, which is an early initiator of AD.
Fighting dementia with play
April 9, 2021
A dementia diagnosis turns the world upside down, not only for the person affected but also for their relatives, as brain function gradually declines. Those affected lose their ability to plan, remember things or behave appropriately. At the same time, their motor skills also deteriorate. Ultimately...
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PLD3 gene contributes to risk of Alzheimer’s disease
April 8, 2021
A rare and controversial mutation in the phospholipase D3 (PLD3) protein -- previously linked to Alzheimer's disease -- interferes with PLD3's vital recycling function inside neurons, according to a new study.
Leaking calcium in neurons an early sign of Alzheimer’s pathology
April 8, 2021
Alzheimer's disease is known for its slow attack on neurons crucial to memory and cognition. But why are these particular neurons in aging brains so susceptible to the disease's ravages, while others remain resilient?
Artificial Intelligence could ‘crack the language of cancer and Alzheimer’s’
April 8, 2021
Powerful algorithms can 'predict' the biological language of cancer and neurodegenerative diseases like Alzheimer's, scientists have found. Big data produced during decades of research was fed into a computer language model to see if artificial intelligence can make more advanced discoveries than hu...
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