alzheimers-dementia

Researchers uncover a protein deficiency in neurons of patients with neurodegenerative diseases that could be targeted by new gene therapy approach

Researchers discovered that a protein called Stathmin-2 is lost in these neurons, which prevents them from regenerating after injury and disrupts their connection with the muscles to control movements.

DNA treatment could delay paralysis that strikes nearly all patients with ALS

Researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.

Solving the Alzheimer's disease puzzle: One piece at a time

Researchers have uncovered a novel regulatory mechanism in the brain that is essential for making the right kinds of proteins that promote healthy brain function, and its malfunctioning may be an early contributor of the development of Alzheimer's disease....
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Transporting antibodies across the blood-brain barrier to treat Alzheimer's disease

Sometimes the best things in life come by chance, when we happen to be in the right place at the right time. Now, researchers have found a way to ensure that new medications are delivered to the right place in the body and at the right point in time during disease progression, so that they have the ...
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MIND and Mediterranean diets associated with fewer Alzheimer's plaques and tangles

People who eat diets rich in green leafy vegetables as well as other vegetables, fruits, whole grains, olive oil, beans, nuts and fish may have fewer amyloid plaques and tau tangles in their brain -- signs of Alzheimer's disease -- than people who do not consume such diets, according to a new study....
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Incident atrial fibrillation appears to heighten dementia risk

People with a recent diagnosis of atrial fibrillation (AF), the most common irregular heart rhythm, have a modestly higher risk of developing dementia than people without the condition, according to new research. The research involved nearly 197,000 patient records from Kaiser Permanente health syst...
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Fresh understanding of aging in the brain offers hope for treating neurological diseases

Scientists have shed new light on aging processes in the brain. By linking the increased presence of specialized immune cells to conditions such as Alzheimer's disease and traumatic brain injury for the first time, they have unearthed a possible new target for therapies aimed at treating age-related...
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Discovery of T cells' role in Alzheimer's, related diseases, suggests new treatment strategy

In Alzheimer's and related neurodegenerative diseases, the brain protein tau is closely linked to brain damage and cognitive decline. A new study indicates that T cells play a key role in tau-related neurodegeneration, a finding that suggests new treatment strategies for Alzheimer's and related dise...
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Scientists show how gene expression controls synaptic plasticity in the aging human brain

Cognitive decline associated with aging is caused by the loss of cholinergic nerve supply to the hippocampus of our brain. Since the hippocampus is the center of learning and memory, a reduction in its synaptic functions leads to cognitive disorders like Alzheimer's disease. To prevent cognitive dis...
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Modifying messenger RNA may provide a new target for Alzheimer's disease

Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a ...
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