Traumatic Brain Injury (TBI)

Alzheimer’s gene triggers early breakdowns in blood-brain barrier, predicting cognitive decline

New USC research reveals how APOE4, a genetic culprit for Alzheimer's disease, triggers leaks in the brain's plumbing system, allowing toxic substances to seep into the brain areas responsible for memory encoding and other cognitive functions.
The damage is linked to future problems i...
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Implant-free optogenetics minimizes brain damage during neuronal stimulation

A minimally invasive optogenetic technique that does not require brain implants successfully manipulated the activity of neurons in mice and monkeys, researchers report April 29th in the journal . The researchers first genetically engineered neurons to produce a newly developed, extremely light-s...
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When damaged, the adult brain repairs itself by going back to the beginning

When adult brain cells are injured, they revert to an embryonic state, according to new findings published in the April 15, 2020 issue of by researchers at University of California San Diego School of Medicine, with colleagues elsewhere. The scientists report that in their newly adopted immature...
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Novel high-speed microscope captures brain neuroactivities

Our brain contains tens of billions of nerve cells (neurons) which constantly communicate with each other by sending chemical and electrical flashes, each lasting a short one millisecond (0.001 sec). In every millisecond, these billions of swift-flying flashes altogether traveling in a giant star...
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First in-human study of drug targeting brain inflammation supports further development

Linda J. Van Eldik, director of the Sanders-Brown Center on Aging at the University of Kentucky, co-authored a paper reporting the first human clinical study of a drug candidate that suppresses injury and disease-induced inflammation of the brain.
The paper was accepted in February by...
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Brain discovery suggests source of lifelong behavioral issues

Improper removal of faulty brain cells during neurodevelopment may cause lifelong behavioral issues, new research from the University of Virginia School of Medicine suggests. The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer's and...
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Repairing stroke-damaged rat brains

Researchers at Lund University in Sweden have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats' brains. The study has now been published in the research journal ....
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Compound in fruit peels halts damage and spurs neuronal repair in multiple sclerosis

Multiple sclerosis (MS), characterized by increasing muscle weakness and paralysis, has a number of treatments that help stall progression of the disease when used early on in the disease. But the current treatments can hardly reverse damage that has already occurred in brain cells called neurons...
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Scientists reveal brain tumors impact normally helpful cells

When the brain gets injured, star-shaped brain cells called astrocytes come to the rescue. In the case of glioma -- the most common type of primary brain tumor -- this protective action comes at a price.
A new study published in reveals that gliomas alter astrocyte function, which no...
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Chilling concussed cells shows promise for full recovery

In the future, treating a concussion could be as simple as cooling the brain.
That's according to research conducted by University of Wisconsin-Madison engineers, whose findings support the treatment approach at the cellular level.
"There are currently no effective medical trea...
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