New protein function could be key to treatment of drug addiction and behavioral disorders
December 5, 2019
The reward pathway of the brain causes feelings of happiness but is also involved in behavioral disorders like schizophrenia and addiction. A breakthrough study has now identified the role of a protein called Npas4 in the reward pathway, mediated by the well-known proteins MAPK and CBP, opening d...
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Chronic adversity dampens dopamine production
November 13, 2019
People exposed to a lifetime of psychosocial adversity may have an impaired ability to produce the dopamine levels needed for coping with acutely stressful situations.
These findings, published today in , may help explain why long-term exposure to psychological trauma and abuse increa...
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Could hair analysis diagnose schizophrenia?
October 29, 2019
A novel approach to probing the biological origins of schizophrenia has identified excess production of hydrogen sulfide in the brain as a factor....
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Biomarker for schizophrenia can be detected in human hair
October 28, 2019
Working with model mice, post-mortem human brains, and people with schizophrenia, researchers at the RIKEN Center for Brain Science in Japan have discovered that a subtype of schizophrenia is related to abnormally high levels hydrogen sulfide in the brain. Experiments showed that this abnormality...
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Schizophrenia risk gene linked to cognitive deficits in mice
October 24, 2019
Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those common...
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New insights into biological underpinnings of schizophrenia
October 15, 2019
Researchers have implicated 10 new genes in the development of schizophrenia using a method called whole exome sequencing, the analysis of the portion of DNA that codes for proteins. Working with a global consortium of schizophrenia research teams, Tarjinder Singh, PhD, a postdoctoral fellow affi...
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Potential therapy to treat detrimental effects of marijuana
October 15, 2019
As a growing number of U.S. states legalize the medicinal and recreational use of marijuana, an increasing number of American women are using cannabis before becoming pregnant and during early pregnancy often to treat morning sickness, anxiety, and lower back pain. Although emerging evidence indi...
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Core symptom of schizophrenia reversed in adult mice
October 9, 2019
Columbia researchers have restored normal working memory to a mouse model of schizophrenia, eliminating a core symptom of the disorder that, in people, has proven virtually impossible to treat.
Working memory is a fundamental brain process used to retain and recall information on the ...
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'New lead' in hunt for better schizophrenia drugs
October 8, 2019
The so-called negative symptoms of schizophrenia, which include anhedonia, can be particularly debilitating. One recent study attempted to identify their neurological roots.
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The propensity to hear 'voices' in Schizophrenia may be established by infancy
October 2, 2019
Some people suffering from severe mental illness, particularly schizophrenia, hear "voices," known as auditory hallucinations. This symptom, which afflicts more than 80% of patients, is among the most prevalent and distressing symptoms of schizophrenia. Patients "hear voices" speaking to them or ...
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